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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TPR All Species: 29.7
Human Site: S1385 Identified Species: 72.59
UniProt: P12270 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P12270 NP_003283.2 2363 267293 S1385 L K A E I A R S N A S L T N N
Chimpanzee Pan troglodytes XP_514063 2363 267281 S1385 L K A E I A R S N A S L T N N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537167 2427 273798 S1449 L K A E I A R S N A S L T N N
Cat Felis silvestris
Mouse Mus musculus NP_598541 2431 273972 S1459 L K A E I A R S N A S L T N N
Rat Rattus norvegicus NP_001100655 2360 267287 S1385 L K A E I A R S N A S L T N N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516826 2360 266175 S1386 L K A E I A R S N A S L T T S
Chicken Gallus gallus XP_422300 2368 267561 T1388 L K A E I A R T T A S L T T S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001025294 2352 265963 S1388 L K A D A A R S S G S L T T L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477067 2346 262334 L1364 N P E E F K R L Q A E R E H L
Honey Bee Apis mellifera XP_395964 2218 250206 L1275 L Q T E R E N L S K L L T S E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 94.2 N.A. 91.2 94.2 N.A. 87.9 83.8 N.A. 58.9 N.A. 20.1 24.1 N.A. N.A.
Protein Similarity: 100 99.8 N.A. 95.8 N.A. 94.2 97.3 N.A. 94.3 92 N.A. 77.6 N.A. 42.9 46.2 N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 86.6 73.3 N.A. 60 N.A. 20 26.6 N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 93.3 86.6 N.A. 73.3 N.A. 26.6 46.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 80 0 10 80 0 0 0 80 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 10 90 0 10 0 0 0 0 10 0 10 0 10 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 0 0 70 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 80 0 0 0 10 0 0 0 10 0 0 0 0 0 % K
% Leu: 90 0 0 0 0 0 0 20 0 0 10 90 0 0 20 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 0 0 0 0 10 0 60 0 0 0 0 50 50 % N
% Pro: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 10 0 0 0 0 0 0 10 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 10 0 90 0 0 0 0 10 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 70 20 0 80 0 0 10 20 % S
% Thr: 0 0 10 0 0 0 0 10 10 0 0 0 90 30 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _